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CellTox
Associazione Italiana
Tossicologia in Vitro

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InVitroNews


Toxicity Testing in the 21st Century and Alternative Methods

Data:26/11/2010

Toxicity testing is posing increasing challenges tohealth care, industry, the research community, as well as the society as a whole. The complexity of issues at stake is matched by the recognition of theoretical, operational, methodological, and economical constraints that may hamper the efficacy of current procedures in toxicity testing. Likewise, the same constraints have been a powerful drive for the development of new methods, technologies, and scientific approaches to tackle difficulties and overcome bottlenecks.

Building up on recent advances in bio-medicine and biotechnology, the US National Research Council has issued a report entitled “Toxicity testing in the 21st century - A vision and a strategy”, describing a transformative paradigm shift in toxicity testing, “...(1) to provide broad coverage of chemicals, chemical mixtures, outcomes, and life stages, (2) to reduce the cost and time of testing, (3) to use fewer animals and cause minimal suffering in the animals used, and (4) to develop a more robust scientific basis for assessing health effects of environmental agents.”.

This workshop is intended to foster discussions aimed at supporting thinking, research activities and action in the area of toxicity testing, in a perspective of alternative strategies based on the paradigm shift from analysis of apical end-points in animal system towards a clarification of toxicity pathways using cells or cell lines.

Preliminary Program Opening Session
Session 1 – Systemic approaches to toxicity testing
Session 2 – From in vivo tests to high throughput in vitro tests
Round table - Toxicity Testing in the 21st Century

Info:
http://www.ipamitalia.it



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